Predictive Biomarkers in Patients With Advanced Hepatocellular Carcinoma Treated With Atezolizumab Plus Bevacizumab
NCT05173298 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100
Last updated 2024-02-07
Summary
The goal of this observational study is to learn about in patients with advanced hepatocellular carcinoma treated with atezoliozumab and bevacizumab.
In this clinical study, we intend to analyze the multiomics data by analyzing the peripheral blood and tumor tissue before and after treatment of patients with advanced liver cancer receiving systemic drug treatment, and analyzing the correlation with the treatment. This is an exploratory study that aims to discover biomarkers that are highly correlated with treatment response.
Conditions
Interventions
- DRUG
-
atezolizumab plus bevacizumab
1200 mg of atezolizumab plus 15 mg/kg of body weight of bevacizumab intravenously every 3 weeks
Sponsors & Collaborators
-
Boryung Pharmaceutical Co., Ltd
collaborator INDUSTRY -
CHA University
lead OTHER
Principal Investigators
-
Hongjae Chon, MD,PhD · Principal Investigator
Eligibility
- Min Age
- 19 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-08-02
- Primary Completion
- 2024-07-31
- Completion
- 2024-12-31
Countries
- South Korea
Study Locations
More Related Trials
-
A Study to Determine Whether Chemotherapy and Atezolizumab is Better Than Chemotherapy, Bevacizumab and Atezolizumab in Patients With Advanced Liver Cancer
NCT05211323 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Investigation of Predictive Biomarkers in Patients With Advanced BTC Treated With Lenvatinib Plus Pembrolizumab
NCT06648057 ·Status: RECRUITING
-
Identification of Innovative Biomarkers to Predict Outcomes in Hepatocellular Carcinoma Treated With Tremelimumab and Durvalumab
NCT06796114 ·Status: RECRUITING ·Phase: NA
-
The Efficacy and Safety of First-line Treatment Combined With Immunotherapy for Advanced Hepatocellular Carcinoma: a Single Center, Real-world Study
NCT07078292 ·Status: NOT_YET_RECRUITING
-
Deep, Multi-omics Phenotyping to Predict Response, Resistance and Recurrence to Adjuvant Atezolizumab Plus Bevacizumab in Resected Hepatocellular Carcinoma
NCT05516628 ·Status: RECRUITING ·Phase: PHASE2
-
Atezolizumab and Bevacizumab With Combined Radiotherapy for Advanced Hepatocellular Carcinoma
NCT05908916 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Phase I Study of RNA Oligonucleotide, MTL-CEBPA, Atezolizumab and Bevacizumab in Patients With Advanced Hepatocellular Carcinoma.
NCT05097911 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis
NCT06096779 ·Status: RECRUITING ·Phase: PHASE2
-
Safety of Atezolizumab-Bevacizumab in Liver Transplanted Patients With Advanced Hepatocellular Carcinoma
NCT06254248 ·Status: RECRUITING ·Phase: PHASE2
-
ICIs and Anti-VEGF Antibody/TKIs With or Without Interventional Therapy for Advanced HCC
NCT07157969 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma
NCT03434379 ·Status: COMPLETED ·Phase: PHASE3
-
Lenvatinib After Progression on Atezolizumab-bevacizumab in Hepatocellular Carcinoma
NCT06138769 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma
NCT04829383 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Atezolizumab in Combination With Bevacizumab in Spanish Patients With Unresectable or Unsuitable for Locoregional Treatments Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy
NCT04732286 ·Status: TERMINATED ·Phase: PHASE3
-
PD-L1 Antibody + Bevacizumab With Hepatic Arterial Infusion Chemotherapy for Advanced HCC
NCT06742424 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma
NCT02519348 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Atezolizumab and Bevacizumab Before Surgery for the Treatment of Resectable Liver Cancer
NCT04721132 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study Investigating the Association of NP137 With Atezolizumab-Bevacizumab Combination in First Line in Unresectable HCC
NCT05546879 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Atezolizumab-bevacizumab and Other Immunotherapies: Real-life Experience for Treatment of Hepatocellular Carcinoma
NCT06806579 ·Status: RECRUITING
-
Trajectory-Based Prognostic Modeling in Hepatocellular Carcinoma
NCT07204262 ·Status: COMPLETED
-
An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery
NCT06117891 ·Status: ACTIVE_NOT_RECRUITING
-
Atezolizumab+Bevacizumab+SBRT in Unresectable HCC
NCT05096715 ·Status: RECRUITING ·Phase: PHASE1
-
Atezolizumab Plus Bevacizumab With HCC and HBV Infection
NCT04180072 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Clinical Feasibility of Microwave Ablation Using Two Channel Microwave Generator and Two Antennas for Small Hepatocellular Carcinoma
NCT06086002 ·Status: COMPLETED ·Phase: NA
-
Trial of Atezolizumab and Bevacizumab With SRF388 or Placebo in Patients With Hepatocellular Carcinoma
NCT05359861 ·Status: COMPLETED ·Phase: PHASE2