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Intraarticular Dextrose Prolotherapy for Symptomatic Knee Osteoarthritis

NCT05160532 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2025-06-12

No results posted yet for this study

Summary

The purpose of this research is to learn more about treating Symptomatic Knee Osteoarthritis (OA) with an ultrasound-guided hypertonic dextrose injection. Researchers would like to determine best practice for injection frequency and effectiveness of the dextrose injection for symptomatic knee OA.

Conditions

Interventions

DRUG

Placebo

5ml of normal saline (NS)

DRUG

Dextrose prolotherapy (DPT)

25% dextrose, mixing 2.5ml of sterile water and 2.5ml of 50% dextrose.

Sponsors & Collaborators

Principal Investigators

  • David Patchett, DO · Mayo Clinic

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-10
Primary Completion
2025-05-31
Completion
2025-05-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs
Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05160532 on ClinicalTrials.gov