MedTrace Logo

Clinical Relevance of Nicardipine Induced Hypoxemia in the Intensive Care Unit

NCT05155202 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2024-02-13

No results posted yet for this study

Summary

In the context of postoperative hypertension in the intensive care units, or after resusitation of hypertensive patients, intravenous antihypertensive drugs are often used. Among those drugs, Nicardipine is an effective drug, but with side effects such as inhibition of pulmonary vasoconstriction. Only preclinical studies have investigated the pathophysiology of this mechanism, and no clinical study have proven its clinical relevance.

The aim of this study is to establish the incidence of Nicardipine induced hypoxemia and to compare it to another antihypertensive agent, Urapidil.

Conditions

  • Hypoxemic Respiratory Failure
  • Side Effect
  • Hypertensive Emergency

Interventions

DRUG

Antihypertensive Agents

Administration of intravenous Nicardipine or Urapidil

Sponsors & Collaborators

  • University Hospital, Caen

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-15
Primary Completion
2023-11-15
Completion
2024-10-15

Countries

  • France

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05155202 on ClinicalTrials.gov