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Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

NCT05147909 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 124

Last updated 2026-02-17

No results posted yet for this study

Summary

Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.

Conditions

  • Physical Inactivity
  • Phosphate Overload
  • Visceral Obesity

Interventions

DIETARY_SUPPLEMENT

Sodium Phosphate

Sodium Phosphate 2 capsules daily (containing a total of 500 mg of Pi, 372mg of sodium)

DIETARY_SUPPLEMENT

Sodium Chloride

Sodium Chloride 2 capsules daily (NaCl, containing a total of 372mg of sodium)

Sponsors & Collaborators

  • University of Texas Southwestern Medical Center

    lead OTHER

Principal Investigators

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-14
Primary Completion
2027-03-31
Completion
2028-03-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05147909 on ClinicalTrials.gov