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Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus Hydrochlorothiazide

NCT05125224 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 163720

Last updated 2025-11-06

Study results available
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Summary

This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication.

Conditions

Interventions

DRUG

Dihydropyridine calcium channel blocker

Dihydropyridine calcium channel blocker claim is used as the exposure group.

DRUG

Hydrochlorothiazide

Hydrochlorothiazide claim is used as the reference group.

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • Rutgers University

    collaborator OTHER

  • Johns Hopkins University

    collaborator OTHER

  • Brigham and Women's Hospital

    lead OTHER

Principal Investigators

  • Madhav Thambisetty, MD, PhD · National Institute on Aging (NIA)

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-01
Primary Completion
2023-07-07
Completion
2023-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05125224 on ClinicalTrials.gov