Trial Outcomes & Findings for Neural Basis of Sensory and Motor Learning: Functional Connections (NCT NCT05124301)
NCT ID: NCT05124301
Last Updated: 2026-01-28
Results Overview
Brain activity was measured during a 12-minute resting-state functional magnetic resonance imaging (fMRI) scan. Resting-state functional connectivity between the ventral premotor cortex (PMv) and primary motor cortex (M1) was quantified as the Pearson correlation coefficient between the mean blood-oxygen-level-dependent (BOLD) time series extracted from anatomically defined PMv and M1 regions of interest. Correlation coefficients were Fisher z-transformed to improve normality. For each participant, connectivity values were averaged across all scans acquired during the main session. The outcome measure is the mean Fisher z-transformed correlation value (unitless). Numbers range from -1 (opposite activity in the two regions) to 1 (similar activity in the two regions), with 0 implying no relationship between the two regions.
COMPLETED
NA
76 participants
3 scans during the main session (2 hours)
2026-01-28
Participant Flow
Participants were recruited through flyers posted in the community that invited people to contact the study team.
Participant milestones
| Measure |
Perceptual Learning
Reaching task in which visual information about target finger position is offset to induce a change in perception of the finger.
Perceptual learning: Reaching task with visual feedback offset from target finger position.
|
|---|---|
|
Overall Study
STARTED
|
76
|
|
Overall Study
COMPLETED
|
68
|
|
Overall Study
NOT COMPLETED
|
8
|
Reasons for withdrawal
| Measure |
Perceptual Learning
Reaching task in which visual information about target finger position is offset to induce a change in perception of the finger.
Perceptual learning: Reaching task with visual feedback offset from target finger position.
|
|---|---|
|
Overall Study
Withdrawal by Subject
|
8
|
Baseline Characteristics
Neural Basis of Sensory and Motor Learning: Functional Connections
Baseline characteristics by cohort
| Measure |
Perceptual Learning
n=76 Participants
Reaching task in which visual information about target finger position is offset to induce a change in perception of the finger.
Perceptual learning: Reaching task with visual feedback offset from target finger position.
|
|---|---|
|
Edinburgh handedness inventory
|
90.6 units on a scale
STANDARD_DEVIATION 11.2 • n=41 Participants
|
|
Age, Continuous
|
23.9 years
STANDARD_DEVIATION 5.5 • n=41 Participants
|
|
Sex: Female, Male
Female
|
53 Participants
n=41 Participants
|
|
Sex: Female, Male
Male
|
23 Participants
n=41 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
9 Participants
n=41 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
67 Participants
n=41 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=41 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=41 Participants
|
|
Race (NIH/OMB)
Asian
|
23 Participants
n=41 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=41 Participants
|
|
Race (NIH/OMB)
Black or African American
|
2 Participants
n=41 Participants
|
|
Race (NIH/OMB)
White
|
44 Participants
n=41 Participants
|
|
Race (NIH/OMB)
More than one race
|
7 Participants
n=41 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=41 Participants
|
|
Region of Enrollment
United States
|
76 Participants
n=41 Participants
|
PRIMARY outcome
Timeframe: 3 scans during the main session (2 hours)Population: 55 is the number of participants who completed the final version of the study.
Brain activity was measured during a 12-minute resting-state functional magnetic resonance imaging (fMRI) scan. Resting-state functional connectivity between the ventral premotor cortex (PMv) and primary motor cortex (M1) was quantified as the Pearson correlation coefficient between the mean blood-oxygen-level-dependent (BOLD) time series extracted from anatomically defined PMv and M1 regions of interest. Correlation coefficients were Fisher z-transformed to improve normality. For each participant, connectivity values were averaged across all scans acquired during the main session. The outcome measure is the mean Fisher z-transformed correlation value (unitless). Numbers range from -1 (opposite activity in the two regions) to 1 (similar activity in the two regions), with 0 implying no relationship between the two regions.
Outcome measures
| Measure |
Perceptual Learning
n=55 Participants
Reaching task in which visual information about target finger position is offset to induce a change in perception of the finger.
|
|---|---|
|
Resting-state PMv-M1 Functional Connectivity (Fisher Z-transformed Correlation)
|
0.64 unitless (Fisher z-score)
Standard Deviation 0.13
|
PRIMARY outcome
Timeframe: Measured during the main session (2 hours)Population: 55 is the number of participants who completed the final version of the study.
Measured by comparing where subjects point on the touchscreen when they are estimating visual vs. proprioceptive targets. A person who relies only on vision would have a weighting value of 100%. A person who relies only on proprioception would have a weighting of 0%. A value of 50% would imply equal reliance on vision and proprioception.
Outcome measures
| Measure |
Perceptual Learning
n=55 Participants
Reaching task in which visual information about target finger position is offset to induce a change in perception of the finger.
|
|---|---|
|
Weighting of Vision vs. Proprioception
|
43.9 Percent
Standard Deviation 23.4
|
Adverse Events
Perceptual Learning
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place