Analysis of the Immunobiology of Acute Myeloid Leukemia Relapses After Allogeneic Hematopoietic Stem Cell Transplant (HSCT) for the Generation of Guidelines and Personalized Therapeutic Pathways
NCT05124288 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 500
Last updated 2025-05-13
Summary
This is a retrospective and prospective non-interventional multicenter observational study. Neither diagnostic approaches nor experimental drugs/procedure will be applied and the samples will take place at the same time as the samples will be taken during routinary clinical practice.
The aim of this study is to analyze the immunobiology of Acute Myeloid Leukemia (AML) relapses after allogeneic HSCT for the generation of guidelines and personalized therapeutic pathways.
Conditions
- Acute Myeloid Leukemia, in Relapse
Interventions
- OTHER
-
Observations on Relapsed AML Allogeneic Transplanted patients
This is not an interventional clinical study. This is a retrospective/prospective observational study on Relapsed AML Allogenic Transplanted patients. Additional samples will be collected during the standard practice.
Sponsors & Collaborators
-
Gruppo Italiano Trapianto di Midollo Osseo
collaborator OTHER -
Associazione Italiana per la Ricerca sul Cancro
collaborator OTHER -
Ciceri Fabio
lead OTHER
Principal Investigators
-
Fabio Ciceri, MD · IRCCS Ospedale San Raffaele
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-07-18
- Primary Completion
- 2026-12-20
- Completion
- 2027-06-20
Countries
- Italy
Study Locations
More Related Trials
-
Molecular Evaluation of AML Patients After Stem Cell Transplant to Understand Relapse Events
NCT05224661 ·Status: ACTIVE_NOT_RECRUITING
-
Relapsed Malignant Blood Cancer After Allogeneic Hematopoietic Stem Cell Transplantation
NCT01326728 ·Status: TERMINATED
-
Sequential Conditioning in Haploidentical Transplantation for Refractory Acute Myeloid Leukemia
NCT03035422 ·Status: COMPLETED ·Phase: NA
-
The Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation in Newly Diagnosed High-relapse-risk CEBPA Mutant Acute Myeloid Leukemia
NCT06458257 ·Status: RECRUITING
-
Immediate Allogeneic Hematopoietic Stem Cell Transplantation Versus Re-treatment for Patients With High-Risk Acute Myeloid Leukemia
NCT06643195 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Decoding the Inflammasome Influence on Treatment Response in Acute Myeloid Leukemia
NCT06535113 ·Status: RECRUITING
-
AML Therapy With Irradiated Allogeneic Cells
NCT02105116 ·Status: TERMINATED ·Phase: NA
-
Prognostic Values of Next Generation Sequencing (NGS) in Acute Myeloid Leukemia Patients With Allo-HSCT
NCT03715621 ·Status: UNKNOWN
-
Early Tapering of Immunosuppressive Agents to Immunomodulation to Improve Survival of AML Patients
NCT03150134 ·Status: UNKNOWN ·Phase: PHASE4
-
High Dose Donor Hematopoietic Stem Cell Infusion for Relapsed/Refractory AML
NCT03080922 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Consolidation Therapy for Acute Myeloid Leukemia Guided by Leukemia Stem Cell Behavior
NCT01588951 ·Status: TERMINATED ·Phase: PHASE2/PHASE3
-
Novel Drugs After Allo-HSCT in Patients With Multiple Myeloma
NCT04506320 ·Status: COMPLETED
-
Sequential Intensive Chemotherapy Followed by RIC for Refractory and Relapse AML
NCT01496547 ·Status: COMPLETED ·Phase: PHASE2
-
Effectiveness and Safety of InO±DLI for Relapsed B-ALL/LBL After Allo-HSCT
NCT06861348 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
GITMO AML/MDS-Relapse Registry Study
NCT06790680 ·Status: COMPLETED
-
A Remission Induction Therapy and Risk-oriented Postremission Strategy for Adult Acute Myelogenous Leukemia (AML)
NCT00495287 ·Status: COMPLETED ·Phase: PHASE3
-
Allogenic Stem Cell Transplantation for Children, Adolescents and Young Adults With Relapsed or Refractory AML
NCT00606723 ·Status: COMPLETED ·Phase: PHASE3
-
Leukemia Stem Cell Detection in Acute Myeloid Leukemia
NCT02927938 ·Status: TERMINATED ·Phase: PHASE3
-
Immune Reconstitution After Allo-HSCT and Blinatumomab
NCT06075212 ·Status: NOT_YET_RECRUITING
-
Impact of Remission Induction Chemotherapy Prior to Allogeneic SCT in Relapsed and Poor-response Patients With AML
NCT02461537 ·Status: COMPLETED ·Phase: PHASE3
-
S0125, Chemotherapy, Total-Body Irradiation, and Peripheral Stem Cell Transplantation in Treating Older Patients With Acute Myeloid Leukemia
NCT00053014 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Siremadlin Alone and in Combination With Donor Lymphocyte Infusion in Acute Myeloid Leukemia Post-allogeneic Stem Cell Transplant
NCT05447663 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Allogeneic HCT Using Uniform Conditioning Regimen Regardless of Donors (MS, MU, or HF) for AML in Remission
NCT03337568 ·Status: UNKNOWN
-
Trial to Find and Investigate a Safe Dose of F16IL2 and BI 836858 in Patients With AML Relapse After Allogeneic Hematopoietic Stem Cell Transplantation
NCT03207191 ·Status: COMPLETED ·Phase: PHASE1
-
Autologous Bone Marrow Transplantation in Acute Non-Lymphoblastic Leukemia During First or Subsequent Remission
NCT00186381 ·Status: COMPLETED ·Phase: PHASE2