Resilience and Brain Health of Older Adults (MEDEX-2)

Summary

This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.

Conditions

• Age-related Cognitive Decline

Interventions

BEHAVIORAL

Mindfulness-Based Stress Reduction

Mindfulness-Based Stress Reduction

BEHAVIORAL

Exercise

Exercise

BEHAVIORAL

Mindfulness-Based Stress Reduction + Exercise

Mindfulness-Based Stress Reduction + Exercise

BEHAVIORAL

Health Education

Health Education

Sponsors & Collaborators

• University of California, San Diego

  collaborator OTHER

• National Institutes of Health (NIH)

  collaborator NIH

• National Institute on Aging (NIA)

  collaborator NIH

• Washington University School of Medicine

  lead OTHER

Principal Investigators

• Eric J Lenze, MD · Washington University School of Medicine

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

FACTORIAL

Eligibility

Min Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-04-16

Primary Completion

2026-08-31

Completion

2026-08-31

Countries

• United States

Study Locations