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MAL-ED Metabolic: A Follow-Up of Chronic Disease at Puberty

NCT05121935 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 254

Last updated 2021-11-16

No results posted yet for this study

Summary

The concept that the roots of cardiometabolic disease start in early life was established by Dr. David Barker, who documented relationships between low birthweight (as a marker for challenges during gestation) and later cardiovascular disease (CVD). Later work has suggested that post-natal challenges (similar to prenatal ones) may also exhibit links to later cardiometabolic disease, with the strongest links appearing to be between low weight in early childhood and later hypertension and high waist circumference (WC). However, assessments for the relationship between early childhood challenges and insulin resistance and glucose regulation have been lacking and long-term cohort studies are few. In this project, we aim to assess children initially followed as part of The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health (MAL-ED) study, where they received frequent measures of anthropometry and laboratory assessments for intestinal pathogens. These children are now of peri-pubertal age--a time period associated with metabolic shifts. We will assess for glucose dysregulation and findings associated with the metabolic syndrome, and we will analyze potential associations between current chronic disease risk findings with early life poor growth and intestinal pathogen carriage rate. As such, we hope to uncover potential targets in early life health to reduce later chronic disease risk.

Conditions

  • Growth Failure
  • Intestinal Infection
  • Metabolic Syndrome
  • Glucose Intolerance

Sponsors & Collaborators

  • Haydom Lutheran Hospital

    collaborator OTHER

  • University of Virginia

    lead OTHER

Principal Investigators

  • Mark D DeBoer, MD · University of Virginia

  • Estomih Mduma, MPH · Haydom Global Health Research Centre

Eligibility

Min Age
9 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-01
Primary Completion
2023-02-01
Completion
2031-02-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05121935 on ClinicalTrials.gov