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Pre-emptive Intravenous Morphine for Acute Post-craniotomy Pain.

NCT05117034 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 115

Last updated 2024-11-20

No results posted yet for this study

Summary

We propose a double-blind randomized controlled trial to evaluate the effect of intravenously administered morphine at surgery conclusion on acute postoperative pain in patients recovering from craniotomy surgery. Participating adults having craniotomy surgery will be randomized in a 1:1 ratio to intraoperative intravenous administration of 0.08 mg/kg morphine at dura closure, or a matching placebo.

Conditions

  • Pain, Postoperative
  • Anesthesia
  • Analgesia

Interventions

DRUG

Morphine

Intraoperative intravenous administration of 0.08 mg/kg morphine at dura closure.

DRUG

Nacl 0.9%

Intraoperative intravenous administration of 0.08 ml/kg NaCl 0.9% at dura closure.

Sponsors & Collaborators

  • Tel-Aviv Sourasky Medical Center

    lead OTHER_GOV

Principal Investigators

  • Or Goren, MD · Department of Anesthesia, Intensive Care, and Pain Management, Tel-Aviv Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-16
Primary Completion
2025-05-01
Completion
2025-05-01

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05117034 on ClinicalTrials.gov