Addiction in Intensive Cardiac Care Units

Summary

Background:

Illicit drug use is a growing issue in Europe and leading cause of acute cardiac events in patients admitted to intensive cardiac care units. Indeed, cardiovascular complications are one of the main causes of death due to illicit drug use. However, its prevalence in patients hospitalized in intensive cardiac care units is unknown.

Objectives:

This large multicenter prospective study will assess the prevalence of illicit drug use in consecutive patients hospitalized in intensive cardiac care units by urine drug assay.

Eligibility:

* Patient over 18 years old admitted to intensive Cardiac Care Unit (CCU) for any reason.
* Without hospitalization for a planned interventional procedure.
* Without hospitalization for more than 24 hours at any hospital facility before admission to the CCU.

Design:

* Multicentre cohort study with a prospective enrolment of all consecutive patients admitted to the CCU to assess the prevalence of illicit drug use in 40 centers throughout France.
* Participants will be screened with a physical exam, medical history and addiction survey.
* Participants will be screened for drug use by urine drug assay (NarcoCheck®, Kappa City Biotech SAS, Montluçon, France) and for tobacco by standardized exhaled carbon monoxide (CO) measurement with a CO-Check Pro device (Bedfont Scientific Ltd, Kent, UK).
* Participants will be followed at 6 months of follow-up to assess the occurrence of cardiovascular events.

Conditions

• Intensive Care Unit Syndrome
• Drug Abuse
• Substance-Related Disorders
• Cardiovascular Events
• Cardiac Disease

Interventions

OTHER

urine test

The following illicit drugs will be evaluated for all consecutive patients by urine drug assay (NarcoCheck®, Kappa City Biotech SAS, Montluçon, France) within two hours of admission to the ICCU: i) cannabinoids (tetrahydrocannabinol \[THC\]), including cannabis and hashish; ii) cocaine and metabolites, including cocaine and crack; iii) amphetamines; iv) MDMA; and v) heroin and other opioids. In addition to the analysis of psychoactive drug use, the investigators will also use the NarcoCheck® urine drug assay to evaluate the associated use of the following psychostimulant drugs: barbiturates, benzodiazepines, tricyclic antidepressant drugs, methadone and buprenorphine.

OTHER

Fagerström questionnaire

Tobacco consumption will also be evaluated for each patient using a Fagerström questionnaire.

OTHER

Exhaled carbon monoxide (CO) measurement

Active smoking will also be systematically investigated in all patients using a standardized exhaled carbon monoxide (CO) measurement with a CO-Check Pro device (Bedfont Scientific Ltd, Kent, UK) on arrival, with a measure of \> 3 parts per million (ppm) signifying active smoking.

Sponsors & Collaborators

• Fondation Coeur et Recherche

  collaborator UNKNOWN

• Assistance Publique - Hôpitaux de Paris

  lead OTHER

Principal Investigators

• Jean-Guillaume DILLINGER, MD,PhD · Lariboisière Hospital, APHP, Paris

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-04-06

Primary Completion

2021-06-06

Completion

2023-04-30

Countries

• France

Study Locations