The Registry of Genetic Alterations of Taiwan Biliary Tract Cancer

Summary

Recent progress in comprehensive genomic profiling for advanced BTC has helped to clarify tumorigenesis and facilitate the coming era of precision medicine. To further elucidate the underlying molecular genomic aberrations, as well as the clinical demographics and therapeutic outcomes, it is necessary to have a national, multi-centers and population-focused research project to collect data completely. Tumor tissue will be collected from advanced BTC patients for real-time next-generation sequencing analysis in a platform of data storage and sharing. The purpose of the precision medicine project is to establish tumor molecular profiling of BTC populations in Taiwan, to facilitate patients to have corresponding potential targeted therapeutics and suitable clinical trials.

Conditions

• Biliary Tract Cancer (BTC)

Interventions

GENETIC

next-generation sequencing

Tumor tissue will be collected from advanced BTC patients for real-time next-generation sequencing analysis

Sponsors & Collaborators

• National Taiwan University Hospital

  collaborator OTHER

• Taipei Veterans General Hospital, Taiwan

  collaborator OTHER_GOV

• Tri-Service General Hospital

  collaborator OTHER

• Chang Gung Medical Foundation (Linkou Branch)

  collaborator UNKNOWN

• Taipei Medical University Shuang Ho Hospital

  collaborator OTHER

• Koo Foundation Sun Yat-Sen Cancer Center

  collaborator OTHER

• China Medical University Hospital

  collaborator OTHER

• National Cheng-Kung University Hospital

  collaborator OTHER

• Kaohsiung Medical University Chung-Ho Memorial Hospital

  collaborator OTHER

• Chang Gung Memorial Hospital

  collaborator OTHER

• Chang Gung Memorial Hospital, Chiayi

  collaborator UNKNOWN

• Taoyuan General Hospital, Ministry of Health and Welfare

  collaborator UNKNOWN

• Mackay Memorial Hospital

  collaborator OTHER

• National Health Research Institutes, Taiwan

  lead OTHER

Principal Investigators

• Li-Tzong Chen, MD · National Health Research Institutes, Taiwan

• Ming-Huang Chen, MD, PhD · Taipei Veterans General Hospital, Taiwan

• Nai-Jung Chiang, MD, PhD · National Health Research Institutes, Taiwan

Eligibility

Min Age

20 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-10-25

Primary Completion

2030-12-31

Completion

2030-12-31

Countries

• Taiwan

Study Locations