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Assessing the Ontogeny of P-glycoprotein Expression in Blood of Pediatric Leukemic Patients

NCT05021159 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2021-09-02

No results posted yet for this study

Summary

Determine P-glycoprotein expression in blood samples of Acute Lymphocytic leukemia (ALL) pediatric patients receiving MTX treatment and trace its ontogeny and compare it with its expression in pediatric healthy subjects. In addition, to determine the correlation of P-glycoprotein expression and Methotrexate concentration at steady state.

Conditions

  • Acute Lymphocytic Leukemia

Interventions

OTHER

MTX, (but the investigator is not using any intervention, the participants are already taking it in their treatment protocol and the investigator is just analyzing p-gp expression)

the investigator is not using any intervention, the participants are already taking it in their treatment protocol and the investigator is just analyzing p-gp expression

Sponsors & Collaborators

  • Tanta University

    lead OTHER

Principal Investigators

  • Yasmine M Elmorsi, Msc · Assistant lecturer in Clinical Pharmacy Dept., Faculty of pahrmacy, Tanta University

  • Osama M Ibrahim, Professor · Professor in Clinical Pharmacy Dept., Faculty of pahrmacy, Tanta University

  • Tarek M Mostafa, Professor · Assistant Professor in Clinical Pharmacy Dept., Faculty of pahrmacy, Tanta University

Eligibility

Min Age
1 Month
Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-03-01
Primary Completion
2021-06-01
Completion
2021-08-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05021159 on ClinicalTrials.gov