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Natural History Study in Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia

NCT05020743 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2025-08-13

Study results available
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Summary

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare, rapidly progressing, genetic, neurodegenerative disease for which no definitive treatment options and limited information on the natural history of the disease are available. The structural, genetic, and neuropathophysiological abnormalities of ALSP lead to the onset of neurologic symptoms, such as moderate to severe motor and neuropsychiatric impairments. This natural history study will collect data to contribute to the development of future novel therapies that focus on the neuropathophysiological features that underlie ALSP and that are essential to reverse, delay, or stop progression of this debilitating disorder.

Conditions

  • ALSP

Interventions

OTHER

No intervention

Not applicable for a Natural History Study

Sponsors & Collaborators

  • Vigil Neuroscience, Inc.

    lead INDUSTRY

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-13
Primary Completion
2025-05-30
Completion
2025-05-30

Countries

  • United States
  • Brazil
  • Canada
  • Germany
  • Netherlands
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05020743 on ClinicalTrials.gov