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Skin Microbiome Profile in Hailey-Hailey Disease

NCT05007223 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 18

Last updated 2021-08-16

No results posted yet for this study

Summary

"Hailey-Hailey disease is an autosomal dominant disorder caused by a genetic defect in a calcium ATPase (ATP2C1) leading to a defect in keratinocyte adhesion. The characteristic of this disease is the involvement of intertriginous areas of the skin, which are the moist sites including the axillary vault and the inguinal crease. The composition of microbial communities is primarily dependent on the physiology of the skin site and the moist sites have distinct compositions of skin microorganisms. In addition, treatment with doxycycline is often helpful in the management of Hailey-Hailey disease. These findings suggest a role of the skin microbiome in the pathogenesis of Hailey-Hailey disease.

The purpose of this study is to characterize the skin microbiome in patients with Hailey-Hailey disease by the 16S method, to better understand the pathogenesis of the disease and to discover new therapeutic targets in the future.

Conditions

  • Hailey-Hailey Disease

Interventions

DRUG

Doxycycline

200mg/day for 28 days(Given doxycycline to patients with Hailey-Hailey disease)

Sponsors & Collaborators

  • Gangnam Severance Hospital

    lead OTHER

Principal Investigators

  • Sang Eun Lee · Department of Dermatology, Gangnam Severance Hospital, Yonsei University College of Medicine,

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-05-08
Primary Completion
2020-09-18
Completion
2020-09-18

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05007223 on ClinicalTrials.gov