Materno-fetal Consequences of Symptomatic Dengue in Pregnant Wowen in French Guiana

Summary

Symptomatic dengue virus infection in pregnant women could affect the mother, fetus and the newborn at birth. The risks of postpartum hemorrhage, prematurity and low birth weight are increased in dengue fever. Cases of vertical transmission have been described. This study therefore proposes to quantify these risks in a pregnant woman presenting a clinical picture of dengue fever through a prospective, longitudinal and comparative study.

Conditions

• Dengue
• Pregnancy Preterm
• Women
• Fever
• Parturition; Precipitate
• Infant, Newborn

Interventions

OTHER

Biological sampling and collection (serum)

Detection of the dengue virus during the next scheduled biological assessment as part of normal pregnancy monitoring (additional tube of blood) among women from GNES and GNEF groups

OTHER

Biological sampling and collection (placenta)

Detection of dengue virus in the placenta of GE patients (additional tube of placenta)

OTHER

Questionnaire

Questionnaire on the patient's socio-economic conditions (10-minute interview with the Clinical Research Associate, CRA).

OTHER

Data collection

Case Report Form will be completed by a Clinical Research Associate (CRA) from the medical file of the patient concerned and of her child at the 3 visits carried out (Pre inclusion V0 or Inclusion V1, Childbirth V2 and Maternity leave V3).

Sponsors & Collaborators

• Centre Hospitalier de Kourou

  collaborator UNKNOWN

• Centre Hospitalier de l'Ouest Guyanais

  collaborator UNKNOWN

• Centres de Protection Maternelle Infantile Cayenne, Kourou et Saint-Laurent du Maroni

  collaborator UNKNOWN

• Private physicians Cayenne, Kourou et Saint-Laurent du Maroni

  collaborator UNKNOWN

• Private midwife Cayenne, Kourou et Saint-Laurent du Maroni

  collaborator UNKNOWN

• Centre Hospitalier de Cayenne

  lead OTHER

Principal Investigators

• Gabriel CARLES · Centre Hospitalier de Saint-Laurent du Maroni

Eligibility

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2012-07-11

Primary Completion

2015-02-12

Completion

2015-07-11

Countries

• French Guiana

Study Locations