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Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer

NCT04974346 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 455

Last updated 2022-01-25

No results posted yet for this study

Summary

Para-aortic lymph node metastasis is a poor prognostic factor for locally advanced cervical cancer, but false negative diagnosis is easy to occur. The aim of this trial was to investigate whether para-aortic prophylactic radiotherapy improves disease-free survival in patients with positive pelvic lymph nodes below the common iliac artery.

Conditions

Interventions

RADIATION

Paraaortic prophylactic irradiation and pelvic definitive concurrent chemoradiation

The para-aortic area, from left renal vein level to abdominal aorta bifurcation level，will be prophylactic irradiation. The other intervention is the same as control arm.

RADIATION

Pelvic definitive concurrent chemoradiation

Pelvic definitive concurrent chemoradiation, including external beam radiotherapy, concurrent chemotherapy and brachytherapy.

Sponsors & Collaborators

  • Zhejiang Cancer Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-02
Primary Completion
2028-08-01
Completion
2030-08-01

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04974346 on ClinicalTrials.gov