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Neck Cooling as a Non-Invasive Method to Lower Brain Temperature in Healthy Adults

NCT04973085 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2023-09-13

Study results available
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Summary

The objective of this study was to clarify whether neck cooling can be used to non-invasively lower brain temperature in healthy adults.

Conditions

  • Healthy

Interventions

DEVICE

Cold circulated water

Cold water was circulated through an adhesive wrap applied to the front of the neck, overlying the carotid arteries, for 120 minutes. MR thermometry was used to measure core brain temperature in 1-minute intervals throughout the intervention. On a different day, subjects crossed over and repeated the intervention in the other study arm (i.e., cold went to body-temperature, and vice-versa).

DEVICE

Body-temperature circulated water

Body-temperature water was circulated through an adhesive wrap applied to the front of the neck, overlying the carotid arteries, for 120 minutes. MR thermometry was used to measure core brain temperature in 1-minute intervals throughout the intervention. On a different day, subjects crossed over and repeated the intervention in the other study arm (i.e., cold went to body-temperature, and vice-versa).

Sponsors & Collaborators

  • Becton, Dickinson and Company

    collaborator INDUSTRY

  • University of Vermont

    lead OTHER

Principal Investigators

  • Adam S Sprouse Blum, MD · University of Vermont

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-07-22
Primary Completion
2022-03-03
Completion
2022-03-03
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04973085 on ClinicalTrials.gov