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Using Nicotine to Reverse Age-related Auditory Processing Deficits

NCT04971954 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2026-03-27

No results posted yet for this study

Summary

The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.

Conditions

  • Auditory Perceptual Impairment
  • Aging

Interventions

OTHER

Nicotine gum

Nicotine (6 mg) will be administered in the form of polacrilex gum that is available as an over-the-counter medication

OTHER

Placebo gum

The placebo will also be a commercially available gum that resembles the nicotine gum in flavor, size, shape, color, and texture.

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • University of California, Irvine

    lead OTHER

Principal Investigators

  • Fan-Gang Zeng, PhD · University of California, Irvine

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-02-01
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04971954 on ClinicalTrials.gov