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Response Predictors of Theta-burst Stimulation for Depression

NCT04969549 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2024-02-26

No results posted yet for this study

Summary

The study consists of an open label trial designed to treat adult depression with TBS. Our aim is to build capacity in neuroimaging analyses by performing magnetic resonance imaging (MRI) assessments at baseline and after 7-10 days of treatment onset in 70 patients. The scientific goal is to test a hypothesis about treatment action: that TBS will reduce negative bias (which causally maintains negative mood) after 1 week of treatment, and patients who show this neurocognitive change will be the ones who go on to respond clinically after 6 weeks.

Conditions

Interventions

OTHER

Theta burst stimulation

It consists of 20 sessions of iTBS over the dlPFC.

Sponsors & Collaborators

  • Academy of Medical Sciences, UK

    collaborator OTHER

  • University of Sao Paulo

    lead OTHER

Principal Investigators

  • Andre R Brunoni, MD, PhD · FACULDADE DE MEDICINA DA USP

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-13
Primary Completion
2022-11-28
Completion
2023-11-28

Countries

  • Brazil

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04969549 on ClinicalTrials.gov