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2000HIV Trained Innate Immunity in HIV Elite Controllers

NCT04968717 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 109

Last updated 2023-11-27

No results posted yet for this study

Summary

Some individuals are able to spontaneously control HIV replication, the so-called 'elite controllers' (ECs). ECs are crucial for our understanding of HIV infection. While there is more and more evidence pointing towards a role of the innate immune system in elite control, no research has been performed on the role of innate trained immunity in elite control of HIV.

In this cross-sectional case-control study, we will study this role of trained immunity in HIV elite control by comparing ECs both to a non-HIV-infected first-degree relative, and to HIV patients who are not elite controllers. In addition, we will study whether HIV itself can induce a trained innate immunity phenotype.

Conditions

Sponsors & Collaborators

  • Erasmus Medical Center

    collaborator OTHER

  • Onze Lieve Vrouwe Gasthuis

    collaborator OTHER

  • Elisabeth-TweeSteden Ziekenhuis

    collaborator OTHER

  • Radboud University Medical Center

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-08-02
Primary Completion
2021-10-27
Completion
2021-10-27

Countries

  • Netherlands

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04968717 on ClinicalTrials.gov