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The Impact of Carbon Monoxide and Altitude on Vascular Function

NCT04928183 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2022-05-25

No results posted yet for this study

Summary

The CarMA (Carbon Monoxide and Altitude) Study aims to observe the vascular effects of carbon monoxide exposure at low and high altitudes.

Conditions

  • Vasodilation
  • Vasoconstriction

Interventions

OTHER

Carbon monoxide rebreathe

Carbon monoxide exposure to increase blood (Carboxyhemoglobin) COHb safely to \~10%

DRUG

Sodium Nitroprusside

Bolus Sodium Nitroprusside (SNP) injection for endothelium-independent vasodilation measure

DRUG

Phenylephrine Hydrochloride

Bolus Phenylephrine injection for observe α1-mediated vasoconstriction during mild exercise

Sponsors & Collaborators

  • University of Alberta

    lead OTHER

Principal Investigators

  • Sean van Diepen, MD, MSc · University of Alberta

  • Craig Steinback, PhD · University of Alberta

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-10
Primary Completion
2021-08-01
Completion
2022-05-18

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04928183 on ClinicalTrials.gov