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Closed Loop Mechanical Ventilation and ECMO

NCT04925518 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 62

Last updated 2021-06-14

No results posted yet for this study

Summary

Mechanical ventilation and ECMO are both technologies interacting on gas exchange. Nevertheless, besides a consensus paper, no evidence-based guidelines regarding protective lung ventilation on ECMO exist to date. Mechanical Ventilation with Intellivent-ASV, an algorithm driven, closed loop system, provides an opportunity to standardize ventilation on ECMO.

We propose and validate lung protective ventilation with a closed loop ventilation mode in patients with ECMO.

Conditions

  • Acute Respiratory Distress Syndrome
  • Cardiogenic Shock

Interventions

DEVICE

Closed Loop Mechanical Ventilation

Closed loop ventilation mode (Intellivent-ASV+®). Intellivent-ASV+® was initiated by activating the controllers for minute volume, PEEP (range 5 to 18 cmH2O) and fraction of inspired oxygen (FiO2) (range 21 to 100 %). The target shift ranges for CO2-management were set between -2.5 and +2.5 kPa, and for O2-management between -2 and +2 %.

DEVICE

Conventional Mechanical Ventilation

Mechanical ventilation with a conventional mode, usually either biphasic positive airway pressure ventilation (DuoPAP®) or adaptive support ventilation (ASV®)

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Marco Maggiorini · Medizinische Intensivstation D-HOER 27, UniversitatsSpital Zürich

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-03-06
Primary Completion
2018-05-23
Completion
2018-05-23

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04925518 on ClinicalTrials.gov