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Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis

NCT04921696 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2023-05-01

No results posted yet for this study

Summary

Necrotizing enterocolitis (NEC) is a leading cause of mortality among preterm infants.The pathogenesis of NEC remains unclear with conflicting data regarding the role of red blood cell (RBC) transfusion and anemia. A meta-analysis of retrospective studies demonstrated an association between exposure to RBC transfusion and NEC(adjusted odds ratio, 2.0 \[95% confidence interval, 1.6-2.5\]). However, recent observational studies have found no association between RBC transfusion and NEC or have found RBC transfusion to be protective.

Conditions

  • Necrotizing Enterocolitis
  • Anemia
  • Red Blood Cell (RBC) Transfusion

Interventions

OTHER

RBC transfusion

RBC was transfused to the infants.

OTHER

no-RBC transfusion

RBC was not transfused to the infants.

Sponsors & Collaborators

  • Children's Hospital of Chongqing Medical University

    collaborator OTHER

  • Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

    lead OTHER

Eligibility

Min Age
1 Minute
Max Age
28 Days
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04921696 on ClinicalTrials.gov