Community-based Post-exposure Prophylaxis for COVID-19

Summary

Specifically identified Ayurvedic preparations is recommended by ministry of AYUSH as post-exposure prophylaxis to efficaciously prevent a negative person who has come into contact with COVID-19-positive. Traditionally, recommended Ayurvedic preparations have been used as antioxidants, antimicrobial and anti-inflammatory properties. Particularly, Guduchi Ghanvati has been recognised with its ability to control viral attachment, viral replication and induce immune response in pre clinical settings, and found to be one among the most important drugs in Ayurveda to fight against COVID-19.

However, known gap in guideline implementation and its impact on preventing active infection in exposed cases is unclear. Study aimed to increase the use of recommended AYUSH guidelines by having registered AYUSH physicians provide these medications, when indicated, in community based participants after known exposure to the SARS-CoV-2 coronavirus.

Conditions

• Covid19

Interventions

OTHER

Guduchi Ghanvati

500 mg of Samshamani vati or Giloy Ghanavati (Aqueous extract of Tinospora cordifolia) twice daily

OTHER

Standard guidelines

Practice guidelines to follow physical distancing, respiratory and hand hygiene, wear mask

Sponsors & Collaborators

• Aarogyam UK

  collaborator OTHER

• Dr. Sarvepalli Radhakrishnan Rajasthan Ayurved University

  collaborator OTHER

• Samta Ayurveda Prakoshtha, India

  collaborator UNKNOWN

• Padmanabhama Ayurveda Hospital and Research Centre

  collaborator UNKNOWN

• NMP Medical Research Institute

  lead OTHER

Principal Investigators

• Neha Sharma · Aarogyam UK

• Skanthesh Lakshmanan · Niramaya clinic, India

• Isha Goyal · NMP Medical Research Institute, India

• Abijith Venu · Aarogyam UK

• Sahil Singhal · NMP Medical Research Institute

• Abhimanyu Kumar · Dr. Sarvepalli Radhakrishnan Rajasthan Ayurved University

Study Design

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-05-03

Primary Completion

2021-05-21

Completion

2021-06-06

Countries

• India

Study Locations