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Absorption and Safety of Topical Timolol to Treat Chronic Wounds

NCT04903366 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2021-05-27

No results posted yet for this study

Summary

Topical timolol has been used primarily as eye drops to treat glaucoma for many years. Recent clinical experience has broadened its off-label use for a number of skin conditions, including slow-healing wounds. While there have been extensive safety studies performed on timolol administration to treat the eye, to date, no studies have documented absorption of timolol after applied on chronic wounds. Thus, the purpose of this study is to determine the blood levels of timolol in patients after topical administration to a chronic wound, and compare these levels with those of patients after administration of the same drug formulation on the eye for the indication of glaucoma.

Conditions

  • Glaucoma, Open-Angle
  • Chronic Wounds

Interventions

DRUG

Timolol Maleate

timolol maleate 0.5% gel-forming solution

Sponsors & Collaborators

  • VA Northern California Health Care System

    lead FED

Principal Investigators

  • Rivkah R Isseroff, MD · VA Northern California Health Care System

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-11-21
Primary Completion
2018-03-09
Completion
2020-01-14
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04903366 on ClinicalTrials.gov