Prospective COVID-19 Cohort Study, Dominican Republic

Summary

This project will build on an existing CDC funded cooperative agreement in the Dominican Republic with the Brigham and Women's Hospital (2018-2023) that includes (i) prospective COVID-19 and AFI surveillance at two health facilities and (ii) a nationally representative cross-sectional community-based serological survey of approximately 7,000 healthy adults and children targeting SARS-CoV-2 and other AFI pathogens to be conducted between April and June 2021. This linked study will establish a nested cohort of 2,000 participants enrolled in the national serological survey and prospectively monitor them for COVID-19 symptoms, conduct serial serological testing, implement molecular surveillance for SARS-CoV-2 and sequencing for variants of concern, implement and evaluate WASH mitigation measures, and monitor uptake and perceptions of COVID-19 vaccines.

Conditions

• SARS-CoV-2 Infection
• Covid19

Interventions

OTHER

Alcohol based hand sanitizer

Provision of ABHS to randomly selected households

Sponsors & Collaborators

• Centers for Disease Control and Prevention

  collaborator FED

• London School of Hygiene and Tropical Medicine

  collaborator OTHER

• The University of Queensland

  collaborator OTHER

• Yale University

  collaborator OTHER

• Broad Institute of MIT and Harvard

  collaborator OTHER

• Ministerio de Salud Publica y Asistencia Social, Republica Dominicana

  collaborator OTHER_GOV

• Brigham and Women's Hospital

  lead OTHER

Principal Investigators

• Eric J Nilles, MD · Brigham and Women's Hospital

Study Design

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

2 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-08-18

Primary Completion

2022-11-22

Completion

2023-02-10

Countries

• Dominican Republic

Study Locations