Infectious Pathogens in Acute Respiratory Illness in Adults and Elderly

Summary

The aim of this study is to generate epidemiological data to further explore determinants of Chronic Obstructive Pulmonary Disease (COPD) and the contribution of bacterial and viral pathogens to Acute Exacerbation of COPD (AECOPD) episodes.

Conditions

• Respiratory Disorders

Interventions

PROCEDURE

Blood sample

Blood samples will be collected from all patients at enrolment, at follow-up visits, at exacerbation visits, and during the final visit.

PROCEDURE

Sputum sample

Sputum will be collected from all patients at enrolment, at monthly follow-up visits, at exacerbation visits, and during the final visit. Sputum will be obtained by spontaneous expectoration or induced by stimulation according to standard methods.

PROCEDURE

Nasopharyngeal swab

Nasopharyngeal swabs will be collected from all patients at enrolment and from a subcohort of 30 patients at monthly follow-up visits and at exacerbation visits during the first year.

PROCEDURE

Urine sample

Urine samples will be taken at enrolment and exacerbation visits from all subjects and from the same subcohort of 30 patients providing nasopharyngeal swabs, at monthly follow-up visits during the first year.

PROCEDURE

End tidal breath sample

Breath samples will be collected from all patients at enrolment, at follow-up visits (monthly), at exacerbation visits, and during the final visit.

OTHER

Data collection

Patient interview, diary cards review and questionnaires completion

OTHER

Tests

Urine pregnancy test, chest CT-scan, lung function testing and 6-min walk test

Sponsors & Collaborators

• GlaxoSmithKline

  lead INDUSTRY

Principal Investigators

• GSK Clinical Trials · GlaxoSmithKline

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

40 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-06-30

Primary Completion

2014-06-27

Completion

2014-06-27

Countries

• United Kingdom

Study Locations