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Healthy Age-dependent Reference Values for Microvascular Structure and Function

NCT04897191 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2021-05-21

No results posted yet for this study

Summary

The greatest challenge in our ageing society are cardiovascular diseases such as stroke, heart attack, peripheral artery disease of the legs with non-healing wounds (ulcers), or diabetes. How healthy ageing affects the smallest blood vessels (microcirculation) and is not well understood. One reason for this is that no generally available medical instrument has the resolution to study the microcirculation. The recently developed optical coherence tomography angiography (OCTA), currently mainly used by eye doctors, is able to visualise the microcirculation. We have developed an automated software (OCTAVA) to determine metrics to characterise the microcirculation on the layers of density, diameter and tortuosity.

In the current study we aim at providing reference values of these metrics in hands and feet of healthy people according to age together with macrovascular function in arms and legs.

Conditions

  • Vascular Endothelium
  • Microvascular Circulation
  • Arterial Stiffness
  • Healthy Ageing

Interventions

OTHER

Age

Determination of age-dependence

Sponsors & Collaborators

  • University of Surrey

    lead OTHER

Principal Investigators

  • Christian Heiss, Prof. · University of Surrey

Eligibility

Min Age
20 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-05-18
Primary Completion
2021-07-31
Completion
2021-08-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04897191 on ClinicalTrials.gov