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Cariostatic and Remineralizing Effects of Three Different Dental Varnishes

NCT04887389 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 115

Last updated 2024-04-02

No results posted yet for this study

Summary

This study is a randomly, controlled, prospective in vivo study.

The objective of this study is:

To evaluate the cariostatic and re-mineralizing effects of Nano silver fluoride, Nano Hydroxyapatite and sodium fluoride varnishes in caries prevention through:

1. Clinical evaluation using international caries detection and assessment system (ICDAS II visual scoring criteria)
2. Calcium and fluoride content using enamel biopsy

Conditions

  • Dental Caries in Children
  • Cariostatic Agent
  • Resistance, Dental Caries
  • Fluoride Varnishes

Interventions

DRUG

Nano Silver Fluoride varnish

Nano Silver Fluoride(5%) is a new experimental formulation containing silver nanoparticles, chitosan and fluoride combines preventive and antimicrobial properties. It is a yellow solution and safe to be used in humans

DRUG

nano-hydroxyapatite varnish

nano-hydroxyapatite (10%) has antibacterial effect, higher solubility, surface energy and bioactivity and its structure is similar to dental apatite.

DRUG

sodium Fluoride Varnish

Fluoride varnish (5%) applied every six months is effective in preventing caries in the primary and permanent dentition of children and adolescents

Sponsors & Collaborators

  • Nisreen Ibrahim khan

    lead OTHER

Principal Investigators

  • Salwa A Hegazy, PhD · Head of Dental Public Health department

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
7 Years
Max Age
10 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-08-01
Primary Completion
2022-09-01
Completion
2023-02-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04887389 on ClinicalTrials.gov