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Molecular Epidemiology of Hepatitis B in Cayenne General Hospital, French Guiana

NCT04886102 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2021-05-13

No results posted yet for this study

Summary

In South America, the prevalence of HBV is variable but high (\> 8%) in the Amazon basin. In some areas, a third of HBsAg carriers are also infected with HDV, a major comorbidity factor. The pre-core mutations are associated with the negative HBe Ag phenotype which is associated with a more severe course. These mutations are of increasing and high frequency. French Guiana is populated by populations of African, European and Asian origins with chains of viral transmission which are not known and viruses probably of different origins with variable virulence and transmission potentials.

Conditions

  • Hepatitis B, Chronic
  • Adults

Interventions

OTHER

An additional 5 mL venous blood tube taken from patients during their routine medical check-up at the hospital

Research protocol involving the human person (Category 3 - Non-interventional research\_ not related to a health product) Serology, molecular biology, phylogenetic and phylodynamic analyzes of hepatitis B and D

Sponsors & Collaborators

  • Hospital Avicenne

    collaborator OTHER

  • University Hospital, Montpellier

    collaborator OTHER

  • Direction Générale de l'Offre de Soins

    collaborator OTHER_GOV

  • Centre Hospitalier de Cayenne

    lead OTHER

Principal Investigators

  • Mathieu NACHER, MD, PhD · Centre Hospitalier de Cayenne

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-11
Primary Completion
2022-02-01
Completion
2022-02-01

Countries

  • French Guiana

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04886102 on ClinicalTrials.gov