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Effect of Nitrous Oxide on EEG

NCT04884893 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2021-12-10

No results posted yet for this study

Summary

Our recent preclinical observations suggest that monitoring of slow electroencephalogram (EEG) oscillations may be used to predict the efficacy of rapid-acting antidepressants such as ketamine or nitrous oxide. In this project we will carry out critical clinical research on healthy volunteers and study the effects of nitrous oxide on EEG. Results will be used for the design of clinical trials on depressed individuals. The project will be done in collaboration between neuroscientists at the University of Helsinki and clinicians at the Tampere University Hospital.

Conditions

  • Nitrous Oxide
  • Electroencephalography
  • Anesthetic, Inhalation

Interventions

DRUG

Nitrous Oxide

50% nitrous oxide

Sponsors & Collaborators

  • Tampere University

    collaborator OTHER

  • University of Helsinki

    collaborator OTHER

  • Tampere University Hospital

    lead OTHER

Principal Investigators

  • Maija-Liisa Kalliomäki, MD, PhD · Tampere University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-05-21
Primary Completion
2021-09-24
Completion
2021-09-24

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04884893 on ClinicalTrials.gov