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Enteric Neural Precursor Cells (ENPC) in the Human Gut

NCT04880538 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 5

Last updated 2024-03-15

No results posted yet for this study

Summary

The study aim is to acquire human tissues to (a) understand the structure and organization of the human Enteric Nervous System; (b) perform a molecular transcriptomic profile of individual cells residing in the human gut; (c) study the turnover rates of individual cell types by Fluorescence-activated cell sorting-aided C14 dating of cells; and finally (d) culture the human gut-derived cells characterize the human adult enteric neural stem cell and study its potential for Neuro-glial differentiation. This study will advance our knowledge of the the cellular and molecular correlates of changes in the Enteric Nervous System that are associated with disorders of motility.

Conditions

  • Gastrointestinal Dysmotility

Interventions

PROCEDURE

Endoscopic procedure

Endoscopic biopsy of one or more of the following: esophagus, stomach, small bowel, colon, or rectum as part of patient clinical care. Biopsies will be performed during endoscopy or colonoscopy and will be transported to the research laboratory for evaluation.

Sponsors & Collaborators

Principal Investigators

  • Ken Hui, MD · Johns Hopkins University

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-26
Primary Completion
2023-09-11
Completion
2023-09-11

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04880538 on ClinicalTrials.gov