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Validation of Quantitative Myocardial Tissue Characterization Through Non-gated CT

NCT04880317 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2025-07-09

No results posted yet for this study

Summary

The main aim is to validate non-gated 5-min computed tomography myocardial relative enhancement (CT-MRE), which can be readily estimated via contrast-enhanced non-gated chest CT, as a tool for estimating myocardial extracellular volume (ECV) using cardiac magnetic resonance (CMR)-derived ECV as a reference standard in a consecutive series of patients scheduled for cardiac CT.

A secondary explorative aim is to evaluate the presence and extent of possible myocardial alterations in those patients enrolled in the VALETUDO study who have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Conditions

  • Cardiac Disease
  • Covid19
  • Cardiotoxicity
  • Extracellular Space Alteration

Interventions

DIAGNOSTIC_TEST

Cardiac Magnetic Resonance

All enrolled patients will undergo a contrast-enhanced CMR examination for the assessment of extracellular volume

DIAGNOSTIC_TEST

Additional CT acquisition

All enrolled patients will undergo an additional CT scan at 5 minutes post-contrast injection to evaluate myocardial relative enhancement

DIAGNOSTIC_TEST

Blood tests

Patients will undergo blood tests to review hematocrit, Sars-CoV-2 antibody status and cardiac fibrosis biomarkers

Sponsors & Collaborators

  • Ospedale San Raffaele

    collaborator OTHER

  • IRCCS Policlinico S. Donato

    lead OTHER

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-05-07
Primary Completion
2023-05-30
Completion
2023-05-30

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04880317 on ClinicalTrials.gov