Jaktinib and Azacitidine In Treating Patients With MDS With MF or MDS/MPN With MF.
NCT04866056 · Status: TERMINATED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 1
Last updated 2022-12-01
Summary
This phase I/II trial studies how well Jaktinib and azacytidine work in treating patients with myelodysplastic syndromes with myelofibrosis or myelodysplastic syndrome/myeloproliferative neoplasm with myelofibrosis. Giving Jaktinib and azacytidine may be an effective treatment for myelodysplastic syndromes with myelofibrosis or myelodysplastic syndrome/myeloproliferative neoplasm with myelofibrosis.
Conditions
- Myelodysplastic Syndromes
- Myeloproliferative Neoplasms
- Myelofibrosis
Interventions
- DRUG
-
Jaktinib
Jaktinib PO BID
- DRUG
-
Azacytidine SC
Sponsors & Collaborators
-
Suzhou Zelgen Biopharmaceuticals Co.,Ltd
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-09-30
- Primary Completion
- 2022-06-10
- Completion
- 2022-06-10
Countries
- China
Study Locations
More Related Trials
-
A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes
NCT06196203 ·Status: RECRUITING ·Phase: PHASE2
-
Trial of Volasertib With or Without Azacitidine in Patients With Myelodysplastic Syndromes
NCT02721875 ·Status: TERMINATED ·Phase: PHASE1
-
Study of Azacytidine Followed by GM-CSF in Patients With Myelodysplastic Syndrome (MDS)
NCT01542684 ·Status: TERMINATED ·Phase: PHASE2
-
Azacitidine Plus Phenylbutyrate in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome
NCT00004871 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase II Study of Maintenance With Azacitidine in MDS Patients
NCT00446303 ·Status: TERMINATED ·Phase: PHASE2
-
Azacitidine and Erythropoietin Versus Azacitidine Alone for Patients With Low-Risk Myelodysplastic Syndromes
NCT00379912 ·Status: TERMINATED ·Phase: PHASE2
-
Azacitidine and Pembrolizumab in Treating Patients With Myelodysplastic Syndrome
NCT03094637 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of Atezolizumab Administered Alone or in Combination With Azacitidine in Participants With Myelodysplastic Syndromes
NCT02508870 ·Status: COMPLETED ·Phase: PHASE1
-
Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome
NCT03383575 ·Status: RECRUITING ·Phase: PHASE2
-
Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS)
NCT04313881 ·Status: TERMINATED ·Phase: PHASE3
-
Evaluation of Azacitidine in Transfusion Dependent Patients With Low-risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)
NCT01048034 ·Status: COMPLETED ·Phase: PHASE2
-
Azacitidine Plus Amifostine in Treating Patients With Myelodysplastic Syndrome
NCT00005598 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Study to Evaluate Overall Response in Patients With Higher Risk Myelodysplastic Syndromes (MDS) Treated With Azacitidine With or Without Deferasirox.
NCT02159040 ·Status: TERMINATED ·Phase: PHASE2
-
5-Azacytidine With Lenalidomide in Patients With High Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML)
NCT01038635 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study to Investigate the Safety and Clinical Activity of GSK3326595 and Other Agents to Treat Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)
NCT03614728 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Study of Azacitidine With or Without Birinapant in Subjects With MDS or CMMoL
NCT02147873 ·Status: TERMINATED ·Phase: PHASE2
-
The Efficacy of Azacitidine +/- Lenalidomide in High-risk Myelodysplastic Syndrome (MDS)and Acute Myeloid Leukemia (AML) With Del(5q).
NCT01556477 ·Status: UNKNOWN ·Phase: PHASE2
-
Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations
NCT04493138 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Selumetinib and Azacitidine in High Risk Chronic Blood Cancers
NCT03326310 ·Status: RECRUITING ·Phase: PHASE1
-
Azacitidine With or Without Ceplene/Interleukin-2 in Patients With Higher Risk Myelodysplastic Syndromes
NCT01324960 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Azacitidine and Lenalidomide for Acute Myeloid Leukemia
NCT01016600 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Eltrombopag With Decitabine in Advanced Myelodysplastic Syndrome (MDS)
NCT02010645 ·Status: TERMINATED ·Phase: PHASE2
-
Study With Azacitidine in Pediatric Subjects With Newly Diagnosed Advanced Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML)
NCT02447666 ·Status: COMPLETED ·Phase: PHASE2
-
Azacitidine, Darbepoetin Alfa, and Erythropoietin and Filgastrim (G-CSF) in Treating Patients With Myelodysplastic Syndromes
NCT00398047 ·Status: TERMINATED ·Phase: PHASE2
-
Phase II Part 2 Expansion of Oral Rigosertib in Combination With Azacitidine
NCT01926587 ·Status: COMPLETED ·Phase: PHASE1/PHASE2