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Physiological Studies in Post-COVID-19 Syndrome, and the Association With DNA Methylation

NCT04859894 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2021-10-04

No results posted yet for this study

Summary

The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated. This study will recruit subjects with a clinical diagnosis of Post-Covid-19-syndrome) who are scheduled for either of lung function testing, cardiopulmonary exercise testing or cardiac ultrasound. Patients' symptoms will be correlated to physiological measures and compared to predicted values. In addition, in 20 patients, symptoms and physiological measures will be correlated to epigenetical alterations, or DNA-methylation patterns. In addition, a subset of patients will be examined a year after the baseline testing in order to follow the progress of the disease.

Conditions

  • Covid19
  • Cardiopulmonary Disease
  • Dyspnea
  • Lung Function Decreased
  • Epigenetic Disorder

Interventions

DIAGNOSTIC_TEST

Physiological testing

Cardiopulmonary exercise testing, Lung Function Testing and in some cases echocardiography. 20 subjects will perform DNA-methylation testing.

Sponsors & Collaborators

  • Linkoeping University

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-04-20
Primary Completion
2022-06-30
Completion
2022-06-30

Countries

  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04859894 on ClinicalTrials.gov