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Post-Stroke Osteopathy

NCT04845269 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 127

Last updated 2023-06-22

No results posted yet for this study

Summary

The sudden biomechanical inactivation, direct neuro-humoral effects and sustained systemic stress reaction, which commonly occur after stroke or TIA, all may be of relevance in triggering alterations in bone metabolism and remodelling of bone microstructure.

The objectives of this observational pilot study are to characterize falls and fractures and their circumstances (sex and age specific incidence, time course, risk conditions, localization) in ischemic stroke patients, study changes in the bone microstructure after ischemic stroke supported by high-resolution peripheral quantitative Computer Tomography, unravel a molecular mechanisms underlying the increased fracture risk (focus on Wnt-signaling and ß-adrenergic projection), establish risk factors to estimate the risk of falls based on information from gait analysis as well as construct deep learning algorithms to identify bone microstructure parameters for predicting fractures.

Conditions

  • Stroke (CVA) or TIA
  • Fracture
  • Fall

Sponsors & Collaborators

  • Medical University Innsbruck

    collaborator OTHER

  • VASCage GmbH

    lead OTHER

Principal Investigators

  • Michael Knoflach, Assoz.Prof. Priv.-Doz. Dr. · Medical University of Innsbruck, Department of Neurology

Eligibility

Min Age
60 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-03-31
Primary Completion
2023-05-31
Completion
2023-05-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04845269 on ClinicalTrials.gov