Addiction and Behavior Related to Menthol Cigarette Substitutes

Summary

The goal of the proposed study is to examine the abuse liability and substitutability of plausible menthol cigarette alternatives currently on the market, including menthol filtered little cigars (mFLC), menthol roll-your-own (mRYO) pipe tobacco and cigarette tubes, and non-menthol cigarettes (nmC). In addition, the study will elucidate real-time mechanisms including product characteristics and perceived effects associated with greater substitution.

Conditions

• Smoking (Tobacco) Addiction

Interventions

BEHAVIORAL

Menthol cigarettes substitutes

In Phase 1, participants will complete 4 smoking sessions using a different product each session to examine each product's abuse liability.

BEHAVIORAL

Usual brand menthol cigarettes and substitutes

In Phase 2, to assess uptake, changes in subjective effects, and use over time, participants will select their preferred study product from Phase 1 and be instructed to completely substitute the product for their usual brand menthol cigarette for one week.

BEHAVIORAL

Menthol cigarettes substitutes and menthol cigarettes

In Phase 3, participants will complete a final in-lab visit to assess the substitutability of their preferred product from Phases 1 and 2, under simulated ban conditions using a progressive ratio task.

Sponsors & Collaborators

• University of Vermont

  collaborator OTHER

• Brown University

  collaborator OTHER

• National Institutes of Health (NIH)

  collaborator NIH

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• Ohio State University Comprehensive Cancer Center

  lead OTHER

Principal Investigators

• Theodore Wagener, PhD · Ohio State University Comprehensive Cancer Center

Study Design

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-12-16

Primary Completion

2021-08-09

Completion

2021-08-09

Countries

• United States

Study Locations