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Normal Values of Parameters of Thrombin Generation in Function of Different Tissue Factor Concentrations

NCT04842084 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2023-12-01

No results posted yet for this study

Summary

The thrombin generation assay (TGA) is a good tool for measuring clot formation in plasma.TGA using Calibrated Automated Thrombography method, enables the quantification of thrombin concentrations in platelet-rich plasma (PRP) and in platelet-poor plasma (PPP).According to the clinical context, different TF(Tissue Factor) concentrations (1, 5 and 10 pM) can be used to trigger the coagulation cascade.The aim of the study is to determine the normal values of TG (Thrombin Generation) in fresh PRP and in PPP with different TF concentrations.

Conditions

  • Healthy Volunteers

Interventions

BIOLOGICAL

Blood samples

sampling of 10 S-Monovette tubes (Sarstedt) 4.3 ml of blood specifically for the study representing a total blood volume of 43 ml

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Saint Etienne

    lead OTHER

Principal Investigators

  • Brigitte Tardy, MD · CHU de SAINT-ETIENNE

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-23
Primary Completion
2023-03-30
Completion
2023-03-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04842084 on ClinicalTrials.gov