Breast Cancer Patients' Cognitive Symptoms After Information About Chemotherapy-Related Cognitive Symptoms

Summary

Previous cross-sectional studies have shown that informing cancer patients about potential chemotherapy-related cognitive symptoms may negatively affect perceived cognitive symptoms and verbal memory performance. A multicenter, randomized study in newly diagnosed breast cancer patients receiving (neo) adjuvant chemotherapy was performed to evaluate this Adverse Information Effect (AIE) over time and investigated whether inviting patients to self-affirm can reduce such AIEs on perceived cognitive symptoms and cognitive test performance.

Conditions

• Breast Cancer
• Cognitive Symptoms
• Cognitive Decline

Interventions

OTHER

Written information about potential chemotherapy-related cognitive symptoms without self-affirmation

OTHER

Written information about potential chemotherapy-related cognitive symptoms with self-affirmation

Sponsors & Collaborators

• The Netherlands Cancer Institute

  collaborator OTHER

• St. Antonius Hospital

  collaborator OTHER

• Meander Medical Center

  collaborator OTHER

• Ziekenhuisgroep Twente

  collaborator OTHER

• Isala

  collaborator OTHER

• Deventer Ziekenhuis

  collaborator OTHER

• Rijnstate Hospital

  collaborator OTHER

• Franciscus Gasthuis

  collaborator OTHER

• St Jansdal Hospital

  collaborator OTHER

• UMC Utrecht

  collaborator OTHER

• Radboud University Medical Center

  lead OTHER

Principal Investigators

• Enny Das, PhD · Radboud University Medical Center

• Sanne B Schagen, PhD · The Netherlands Cancer Institute

• Gabe S Sonke, PhD, MD · The Netherlands Cancer Institute

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-03-20

Primary Completion

2016-09-23

Completion

2016-09-23