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Neural Correlates of tVNS

NCT04810234 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 16

Last updated 2021-03-22

No results posted yet for this study

Summary

Transcutaneous vagal nerve stimulation (tVNS) has been applied to a number of disease areas including visceral pain, depression, cluster headache and Alzheimer's disease. However, there is marked heterogeneity in these studies pertaining to i) the anatomical site of stimulation (neck, inner concha or tragus of ear), and ii) the waveform parameters of the stimulating impulse. This exploratory cross-sectional study will address these knowledge gaps by comparative functional neuroimaging of the neural correlates of tVNS with disparate anatomical sites and electrical waveform characteristics during rest in healthy participants.

Conditions

  • fMRI
  • Transcutaneous Vagal Nerve Stimulation (tVNS)
  • Nucleus of the Solitary Tract (NTS)

Interventions

DEVICE

transcutaneous vagal nerve stimulation (tVNS)

Cervical and auricular transcutaneous stimulation of the vagus nerve

Sponsors & Collaborators

  • Wingate Institute of Neurogastroenterology

    collaborator OTHER

  • Maastricht University Medical Center

    lead OTHER

Principal Investigators

  • Ad Masclee, MD, PhD · Maastricht University Medical Center

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-11-01
Primary Completion
2021-06-01
Completion
2021-06-01

Countries

  • Netherlands
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04810234 on ClinicalTrials.gov