Psychological and Lifestyle Factors on Health Outcomes

Summary

Psychosocial and lifestyle factors in Army recruits likely contribute to increased susceptibility to infection and injury during basic Army training. The primary aim of this study is to assess the influence of psychosocial and lifestyle factors at the start of basic Army training on immune health (e.g. respiratory infection and antibody response to influenza vaccination) and injury during training, in an observational design.

A secondary aim is to establish whether changes in psychosocial and lifestyle factors during training impact immune health (e.g. response to hepatitis B vaccination). Using an interventional design, participants will be randomly allocated into two experimental groups: (i) Routine vaccination group: to receive first hepatitis B vaccination at initial medical assessment upon entry to basic training and second hepatitis B vaccination 1 month later; (ii) Delayed vaccination group: to receive first hepatitis B vaccination during week 5 of training and second hepatitis B vaccination 1 month later.

Conditions

• Psychological
• Stress
• Immune Health
• Vaccination
• Respiratory Tract Infections
• Injury

Interventions

BEHAVIORAL

Delayed vaccination

First and second hepatitis B vaccinations will be delayed by 1 month in the interventional group to establish whether changes in psychosocial and lifestyle factors during training impact immune health.

Sponsors & Collaborators

• University of Nottingham

  collaborator OTHER

• University of California, Los Angeles

  collaborator OTHER

• Loughborough University

  collaborator OTHER

• Ministry of Defence, United Kingdom

  collaborator OTHER_GOV

• Liverpool John Moores University

  lead OTHER

Principal Investigators

• Neil P Walsh, PHD · Liverpool John Moores University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

16 Years

Max Age

33 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-10-19

Primary Completion

2023-01-31

Completion

2023-01-31

Countries

• United Kingdom

Study Locations