Tislelizumab Plus Anlotinib for Immunotherapy Resistant Gastrointestinal Cancer
NCT04777162 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2021-03-04
Summary
Immunotherapy acquired resistance was observed in clinical practice. The investigators intended to add anlotinib to PD-1 inhibitors, hoping reverse the resistance.
Conditions
- Gastric Cancer
- Colo-rectal Cancer
Interventions
- DRUG
-
Tislelizumab
For included participants, tislelizumab would be administrated 200mg q3w iv.
- DRUG
-
Patients will be administrated with Anlotinib 12mg p.o. d1-d14 q3w.
Sponsors & Collaborators
-
Peking University
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-03-31
- Primary Completion
- 2023-01-31
- Completion
- 2023-05-31
Countries
- China
Study Locations
More Related Trials
-
Study of Anlotinib in Patients With Gastric Cancer(ALTER0503)
NCT02461407 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
AK104 in Locally Advanced MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer
NCT04556253 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Assessing Iparomlimab and Tuvonralimab in Recurrent or Metastatic MSI-H/dMMR Gastric Cancer
NCT07127822 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Tislelizumab Combined With Chemotherapy in First-line Treatment of AGC
NCT06034964 ·Status: ACTIVE_NOT_RECRUITING
-
PD-1 Antibody + Apatinib Mesylate in 2+ Line Serum AFP-elevated Gastric Adenocarcinoma
NCT04006821 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
NCT07043400 ·Status: RECRUITING ·Phase: PHASE3
-
Efficacy and Safety of Anlotinib in Patients With Advanced Gastrointestinal Stromal Tumor After Failure of Imatinib: a Prospective, Single Arm and Multicenter Trial
NCT04106024 ·Status: UNKNOWN ·Phase: PHASE2
-
Safety and Efficacy of Glumetinib Combined With Docetaxel for Injection (Albumin-bound) in Patients With Advanced Gastric Cancer/Gastroesophageal Junction Adenocarcinoma and Other Solid Tumors
NCT06947291 ·Status: RECRUITING ·Phase: PHASE2
-
Phase II Study of Neoadjuvant Tislelizumab Plus Radiotherapy and GP Chemotherapy for Borderline/Unresectable Hilar Cholangiocarcinoma
NCT07030140 ·Status: RECRUITING ·Phase: PHASE2
-
Minimal Residual Disease-guided Adjuvant Therapy for Gastric Cancer
NCT06157216 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Fruquintinib and Albumin-paclitaxel Combined With or Without PD-1 Antibody in 2nd-line Treatment of G/GEJ Adenocarcinoma
NCT06417892 ·Status: RECRUITING
-
Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-859/KEYNOTE-859)-China Extension
NCT04859582 ·Status: WITHDRAWN ·Phase: PHASE3
-
Neoadjuvant Tislelizumab With Chemotherapy for the Treatment of MSS Colon Cancer
NCT06124378 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
First-line Treatment with RC48 Plus Tislelizumab and S-1(RCTS) in Advanced Gastric Cancer
NCT05586061 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
An Exploratory Study of Immunotherapy Combined With Anlotinib and Chemotherapy in Perioperative Treatment of LAGC
NCT05800080 ·Status: UNKNOWN ·Phase: NA
-
PD-1 Antibody + XELOX in 1st Line Serum A-fetoprotein (AFP)-Elevated Gastric or Gastroesophageal Junction Adenocarcinoma
NCT04098796 ·Status: UNKNOWN ·Phase: PHASE2
-
Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers
NCT06580574 ·Status: RECRUITING ·Phase: PHASE2
-
Tislelizumab Combined With Chemotherapy (CAPOX) in the Perioperative Treatment of MSI-H/dMMR Stage II or III Colorectal Cancer
NCT05841134 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Study of Tislelizumab in Combination With SOX for the Treatment of Gastric Cancer With Liver Metastases
NCT05325528 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Anlotinib Plus Chemotherapy as First-line Therapy for Gastrointestinal Tumor Patients With Unresectable Liver Metastasis (ALTER-G-001)
NCT05262335 ·Status: UNKNOWN ·Phase: PHASE2
-
Efficacy and Safety of Tislelizumab in Combination With Fruquintinib in Participants With Selected Solid Tumors
NCT04716634 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant Immunotherapy Plus Chemotherapy in Borrmann Type 4 and Large Type 3 Gastric Cancer
NCT06451211 ·Status: RECRUITING ·Phase: PHASE2
-
Safety and Efficacy of an Anticancer Medication Combined With Immune Cells in Subjects With Gastrointestinal Cancer
NCT03474861 ·Status: UNKNOWN ·Phase: PHASE1
-
Tislelizumab Combined With Apatinib and Oxaliplatin Plus S1 Vs Oxaliplatin Plus S1 as Neoadjuvant Therapy for Borrmann IV、Large Borrmann III Type and Bulky N Positive Advanced Gastric Cancer
NCT05699655 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Clinical Study of Pabolizumab for Neoadjuvant Immunotherapy of Locally Advanced Microsatellite-unstable Gastric Adenocarcinoma
NCT05816863 ·Status: UNKNOWN