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Comparison of Posterior Ocular Changes Between Singleton Pregnancy and Multifetal Pregnancy.

NCT04773561 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 166

Last updated 2021-09-05

No results posted yet for this study

Summary

It has been known that a pregnant women undergoes significant anatomical and physiological changes that mainly caused by hormonal and hematologic changes during pregnancy. Due to advance in reproductive medicine, the incidence of multifetal pregnancy was increased to 3% of livebirth. Multifetal pregnancies produce much more physiological changes in the body compared to the singleton pregnancies.

Physiologic ocular changes during pregnancy are the followings

* Melanogenesis of eyelid and facial skin
* Cellular alteration of lacrimal and meibomian gland
* Increased corneal thickness and corneal curvature
* Increased lens thickness
* Increased retinal vascular density
* Increased choroidal thickness Decreased intraocular pressure -

Conditions

  • Twin Pregnancy, Antepartum Condition or Complication
  • Retinal Vascular
  • Choroidal Effusion

Interventions

DEVICE

Corneal tomography, optical coherence tomography and optical coherence tomography angiography

Ocular investigations were performed in one time during 30-36 weeks of gestational age. Due to avoidance of diurnal variation, all examinations were done between 10 am - 12 pm.

Sponsors & Collaborators

  • Khon Kaen University

    lead OTHER

Principal Investigators

  • Suthasinee Sinawat, MD · KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
24 Years
Max Age
37 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-03
Primary Completion
2023-12-30
Completion
2024-06-30

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04773561 on ClinicalTrials.gov