Chloroquine for Glioblastoma.
NCT04772846 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2021-02-26
Summary
Adjuvant chloroquine to the conventional treatment for glioblastoma; A randomized, single-blind, placebo-controlled, phase I/II trial.
Conditions
Interventions
- DRUG
-
Oral tablet
Oral 250mg chloroquine tablets
- DRUG
-
Oral placebo tablets
Sponsors & Collaborators
-
Egyptian Medical Syndicate
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- SINGLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2018-03-01
- Primary Completion
- 2020-12-01
- Completion
- 2021-03-31
Countries
- Egypt
Study Locations
More Related Trials
-
IDO2 Genetic Status Informs the Neoadjuvant Efficacy of Chloroquine (CQ) in Brain Metastasis Radiotherapy
NCT01727531 ·Status: COMPLETED ·Phase: NA
-
Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme
NCT00486603 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Randomised Trial Investigating the Additional Benefit of Hydroxychloroquine(HCQ)to Short Course Radiotherapy (SCRT) in Patients Aged 70 Years and Older With High Grade Gliomas (HGG)
NCT01602588 ·Status: COMPLETED ·Phase: PHASE2
-
Pyrazoloacridine Plus Carboplatin in Treating Patients With Recurrent Glioma
NCT00005976 ·Status: COMPLETED ·Phase: PHASE2
-
Repurposing Chlorpromazine in the Treatment of Glioblastoma
NCT04224441 ·Status: UNKNOWN ·Phase: PHASE2
-
Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy
NCT01430351 ·Status: TERMINATED ·Phase: PHASE1
-
Evaluate the Role of Anthracycline After Radio Therapy in Patients With Glioblastoma (pGBM).
NCT06297512 ·Status: RECRUITING ·Phase: PHASE2
-
Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamic Effects of PQR309 in Glioblastoma Patients
NCT02850744 ·Status: TERMINATED ·Phase: PHASE2
-
Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients
NCT03758014 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
AQ4N in Combination With Radiotherapy and Temozolomide in Subjects With Newly Diagnosed Glioblastoma Multiforme
NCT00394628 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma
NCT02728349 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of GDC-0084 in Patients With Progressive or Recurrent High-Grade Glioma
NCT01547546 ·Status: COMPLETED ·Phase: PHASE1
-
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)
NCT05120284 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases
NCT07268053 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
A Study of VRT106 for Injection in Patients With Recurrent/Progressive Glioblastoma
NCT07093814 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
NCT00003996 ·Status: COMPLETED ·Phase: PHASE2
-
Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors
NCT01111097 ·Status: COMPLETED ·Phase: PHASE1
-
A Clinical Trial of P134 Cells in Recurrent Glioblastoma
NCT07318818 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration
NCT04201457 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Chlorpromazine and Standard of Care in Glioblastoma
NCT05190315 ·Status: COMPLETED ·Phase: PHASE1
-
Glutamate Inhibitors in Glioblastoma
NCT05664464 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Vitamin D for Treatment of Glioblastoma Multiforme
NCT01181193 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Phase III Study Comparing 2 Brain Conformational Radiotherapy in Combination With Chemotherapy in the Treatment of Glioblastoma
NCT01507506 ·Status: TERMINATED ·Phase: PHASE3
-
Phase 0 With Expansion Phase Clinical Trial of Quisinostat Plus Radiotherapy in Newly-diagnosed and Recurrent Grade 4 IDH-Wildtype Glioblastomas
NCT06824662 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
Phase I Trial of CC-8490 for the Treatment of Subjects With Recurrent/Refractory High-Grade Gliomas
NCT00074646 ·Status: COMPLETED ·Phase: PHASE1