Precision Medicine in the Prostate Cancer Care Pathway
NCT04763317 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 3000
Last updated 2025-12-16
Summary
This study aims to evaluate the use of a prostate cancer specific predisposition genetic panel test in men with / at high risk of prostate cancer. The genetic test will analyse men's DNA samples for the presence of mutations in rare genes as well as common genetic variation to provide men with information about their risk of prostate cancer. This study will evaluate the clinical impact of the test on risk assessment and clinical management in terms of screening and treatment.
Conditions
- Prostate Cancer
- Genetic Predisposition
Interventions
- GENETIC
-
Prostate cancer risk gene panel
A list of genes created by study experts, thought to increase the risk of prostate cancer from from review previous research, this list is regularly reviewed for accuracy
Sponsors & Collaborators
-
Royal Marsden NHS Foundation Trust
collaborator OTHER -
Institute of Cancer Research, United Kingdom
lead OTHER
Eligibility
- Min Age
- 30 Years
- Max Age
- 70 Years
- Sex
- MALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-02-14
- Primary Completion
- 2029-12-31
- Completion
- 2034-12-31
Countries
- United Kingdom
Study Locations
More Related Trials
-
Prostate Cancer Screening Among Men With High Risk Genetic Predisposition
NCT02053805 ·Status: UNKNOWN ·Phase: NA
-
An Epidemiological Study of Genetic Risk Factors for Prostate Cancer in African-American and Caucasian Males
NCT00342771 ·Status: COMPLETED
-
The BARCODE 2 Study - The Use of Genetic Profiling to Guide Prostate Cancer Treatment
NCT02955082 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Technology-Enhanced Acceleration of Germline Evaluation for Therapy, TARGET Study
NCT04447703 ·Status: COMPLETED ·Phase: NA
-
The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)
NCT05926102 ·Status: RECRUITING ·Phase: NA
-
imPlementing ROutine Molecular Characterization in Patients With Metastatic Castration Resistant ProstaTe Cancer by NGS
NCT04746300 ·Status: UNKNOWN
-
Study of How People Make Decisions About Prostate Cancer Risk
NCT07197723 ·Status: RECRUITING
-
Community-Based Health Coach for Access to Germline Genetic Testing Among African American Men With Prostate Cancer
NCT04763980 ·Status: RECRUITING ·Phase: NA
-
An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)
NCT04720157 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Genetic Testing in Predicting Biomarkers of Recurrence in Patients With Prostate Cancer Undergoing Surgery
NCT00977457 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Phase 2 Study of G-202 in Patients With Chemotherapy-Naïve Metastatic Castrate-Resistant Prostate Cancer
NCT01734681 ·Status: WITHDRAWN ·Phase: PHASE2
-
Development of a Novel Signature Integrating Clinical, Imaging And Epigenetic Information to Tailor Pelvic Nodal Treatment in Prostate Cancer
NCT06807398 ·Status: COMPLETED
-
Study of Blood and Tissue Samples From Patients Receiving Androgen Deprivation for Newly Diagnosed Prostate Cancer
NCT00967954 ·Status: UNKNOWN ·Phase: NA
-
Genetic Studies of Prostate Cancer Aggressiveness and Prognosis
NCT06773858 ·Status: COMPLETED
-
A Study Evaluating [177Lu]Lu-PSMA-617 vs. a Change of Androgen Receptor-directed Therapy in Taxane Treatment Naive Chinese Male Patients With Progressive Metastatic Castrate Resistant Prostate Cancer
NCT05658003 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Nutrition and Lifestyle Changes in Patients With Previously Untreated Stage I or Stage II Prostate Cancer
NCT00739791 ·Status: COMPLETED ·Phase: NA
-
Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial
NCT04513717 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Neoadjuvant Lu-177-PSMA-617 in Patients With High Risk Localized Prostate Cancer Undergoing Radical Prostatectomy
NCT06798558 ·Status: RECRUITING ·Phase: PHASE2
-
A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer
NCT05800665 ·Status: RECRUITING ·Phase: PHASE1
-
Implementation of Precision Medicine in High-risk Prostate Cancer
NCT06687421 ·Status: RECRUITING
-
Active Surveillance in Prostate Cancer
NCT00490763 ·Status: COMPLETED
-
An Open-label Extension Study of PSMA ADC 2301 in mCRPC
NCT02020135 ·Status: COMPLETED ·Phase: PHASE2
-
Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial
NCT06632977 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of DKF-MA102 in Patients With Prostate Cancer
NCT06490328 ·Status: RECRUITING ·Phase: PHASE3
-
Prostate Cancer Prospective Cohort
NCT00937586 ·Status: ACTIVE_NOT_RECRUITING