Pre-operative Risk Assessment of Surgical Site Infection After Cardiac Surgery

Summary

Surgical site infections (SSI) are serious complications accounting for 20% of all the healthcare-associated infections and are considered the second most frequent type of hospital-acquired infection in Europe and the United States. SSI after cardiac surgery is associated with delays to patient's discharge, readmissions and re-operations; and can result in increased hospital costs for staffing, diagnostics and treatment.

Risk assessment has been identified as potentially useful intervention in SSI prevention and in identifying at risk populations who may benefit from specific interventions to reduce this possible complication of cardiac surgery. However, there is currently a lack of evidence as to which risk tools are the most valid and reliable to be used in clinical practice. The investigators developed and locally validated the Barts Heart Centre Surgical Infection Risk (B-SIR) tool to include patients with various types of cardiac surgeries and found that the B-SIR tool is a better tool in predicting SSI risk compared with the existing cardiac risk tools in the study population.

However, various literatures recognised that the predictive performance of a risk model tends to vary across settings, populations and periods. Hence, the investigators aim to do a multi-centre validation of the newly developed B-SIR tool and apply all the other tools (Australian Cardiac Risk Index and Brompton and Harefield Infection Score) to identify what tool performs best that can potentially be use for the UK population. Further, the outcome of the study will be beneficial to future cardiac surgery patients to assess their risk of developing SSI and help identify those patients who may benefit from specific interventions. Existing patients' data, which will be anonymised, from the participating cardiac centres will be utilised to analyse and compare the performance of each risk tools.

Conditions

• Surgical Site Infection
• Risk Assessment
• Cardiac Surgery

Sponsors & Collaborators

• Liverpool Heart and Chest Hospital NHS Foundation Trust

  collaborator OTHER

• University Hospitals, Leicester

  collaborator OTHER

• Oxford University Hospitals NHS Trust

  collaborator OTHER

• South Tees Hospitals NHS Foundation Trust

  collaborator OTHER

• Cardiff and Vale University Health Board

  collaborator OTHER_GOV

• Belfast Health and Social Care Trust

  collaborator OTHER

• Barts & The London NHS Trust

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

120 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-07-15

Primary Completion

2023-11-30

Completion

2023-11-30

Countries

• United Kingdom

Study Locations