Endoprosthesis Metal Toxicity Study

Summary

The purpose of this research is to investigate whether patients who previously had endoprosthesis surgery experience memory, thinking, or heart problems. It will also help determine how often these problems occur.

Conditions

• Bone Tumor
• Cancer of Bone
• Heart Diseases
• Cognitive Impairment
• Cognitive Decline
• Chemotherapy Effect
• Memory Problem

Interventions

BEHAVIORAL

Questionnaires

The patient and an informant will be asked to complete a questionnaire about his or hers current and past physical thinking abilities.

BEHAVIORAL

Interviews

Cognition and memory interviews will take place with the patient.

DIAGNOSTIC_TEST

Blood Test

Three blood draws will occur to assess patients immune response, metal levels, and cardiac health.

DIAGNOSTIC_TEST

Echocardiogram

Each echocardiogram takes about 3 hours and 30 minutes. This test uses sound waves to look at your heart. The person doing the test will press on your chest with a machine to obtain the pictures. The pressure may be uncomfortable. The echocardiogram will involve an image enhancement agent infusion to obtain better images.

Sponsors & Collaborators

• National Institutes of Health (NIH)

  collaborator NIH

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• National Institute on Aging (NIA)

  collaborator NIH

• Mayo Clinic

  lead OTHER

Principal Investigators

• Matthew Houdek, MD · Mayo Clinic

Eligibility

Min Age

18 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-03-19

Primary Completion

2024-05-01

Completion

2024-05-01

Countries

• United States

Study Locations