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Reduction of Blood Recirculation in Veno-Venous ECMO

NCT04754854 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 136

Last updated 2024-12-31

No results posted yet for this study

Summary

Blood which recirculates through the circuit of a veno-venous Extracorporeal Membrane Oxygenation (V-V ECMO) does not contribute to the systemic oxygenation of a patient on V-V ECMO and is called the recirculation fraction (Rf). Theoretically, the optimization of ECMO blood flow is possible using Rf measurements.

A prospective, observational study will be performed measuring the Rf of total ECMO blood flow in patients with acute respiratory distress syndrome (ARDS) on V-V ECMO with an ultrasound dilution technique.

ECMO blood flow will be optimized by reducing ECMO blood flow in accordance with the measured Rf as long as systemic oxygenation is not compromised.

Conditions

  • Extracorporeal Membrane Oxygenation
  • Acute Respiratory Distress Syndrome

Sponsors & Collaborators

  • Charite University, Berlin, Germany

    lead OTHER

Principal Investigators

  • Martin Russ, Dr. med. · Charite University Hospital Berlin

  • Philipp A Pickerodt, Dr. med. · Charite University Hospital Berlin

  • Vladimir Skrypnikov, Dr. med. · Charite University Hospital Berlin

  • Steffen Weber-Carstens, Prof. Dr. med. · Charite University Hospital Berlin

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-20
Primary Completion
2026-08-31
Completion
2026-10-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04754854 on ClinicalTrials.gov