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Use of Prophylactic Steroids in the Prevention of Post-thyroidectomy Hypocalcaemia and Voice Dysfunction

NCT04752852 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 192

Last updated 2021-02-12

No results posted yet for this study

Summary

Total thyroidectomy for benign surgical pathologies is associated with risks related to temporary hypocalcaemia and vocal quality dysfunction. Dexamethasone, as an anti-inflammatory steroid, has been proposed to have a physiological effect on hypocalcaemia and voice quality. Investigators conducted a double-blinded controlled trial to assess the effect of preoperative dexamethasone on the vocal dysfunction and hypocalcaemia following thyroidectomy

Conditions

Interventions

DRUG

Dexamethasone

8 mg/2 ml dexamethasone IV, 60 minutes before the induction of anaesthesia

DRUG

Placebo

2 ml normal saline (0.9%) IV, 60 minutes before the induction of anaesthesia

Sponsors & Collaborators

  • Holy Family Hospital, Pakistan

    lead OTHER

Principal Investigators

  • Raheel Ahmad, FCPS · Holy Family Hospital Rawalpindi Pakistan

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2019-12-31
Completion
2020-07-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04752852 on ClinicalTrials.gov